Characterization and comparison of the human and mouse GLC1A glaucoma genes.
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ABSTRACT:
SUBMITTER: Fingert JH
PROVIDER: S-EPMC310708 | biostudies-literature | 1998 Apr
REPOSITORIES: biostudies-literature
Publications
Characterization and comparison of the human and mouse GLC1A glaucoma genes.
Fingert J H JH Ying L L Swiderski R E RE Nystuen A M AM Arbour N C NC Alward W L WL Sheffield V C VC Stone E M EM
Genome research 19980401 4
The GLC1A gene (which encodes the protein myocilin) has been associated with the development of primary open angle glaucoma. Bacterial artificial chromosomes containing the human GLC1A gene and its mouse ortholog were subcloned and sequenced to reveal the genomic structure of the genes. Comparison of the coding sequences of the human and mouse GLC1A genes revealed a high degree of amino acid homology (82%) and the presence of several conserved motifs in the predicted GLC1A proteins. The expressi ...[more]
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