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Structure of an essential GTPase, YsxC, from Thermotoga maritima.

ABSTRACT: YsxC belongs to the YihA family of TRAFAC class GTPases. The protein is involved in the biogenesis of ribosomes and is essential for the survival of a wide range of bacteria. Here, crystal structures of YsxC from Thermotoga maritima and its complex with GDP were determined at maximal resolutions of 2.3 and 1.9?Å, respectively. Major structural differences are observed in the switch I region, which is disordered in the apo form but exists in both an `open' and a `closed' conformation in the GDP-bound state. A comparison with the structure of the GMPPNP-YsxC complex from Bacillus subtilis provides insights into the mechanism of conformational change in the switch I and II regions upon hydrolysis of GTP.

SUBMITTER: Chan KH

PROVIDER: S-EPMC3107132 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Structure of an essential GTPase, YsxC, from Thermotoga maritima.

Chan Kwok-Ho KH Wong Kam-Bo KB

Acta crystallographica. Section F, Structural biology and crystallization communications 20110524 Pt 6

YsxC belongs to the YihA family of TRAFAC class GTPases. The protein is involved in the biogenesis of ribosomes and is essential for the survival of a wide range of bacteria. Here, crystal structures of YsxC from Thermotoga maritima and its complex with GDP were determined at maximal resolutions of 2.3 and 1.9 Å, respectively. Major structural differences are observed in the switch I region, which is disordered in the apo form but exists in both an `open' and a `closed' conformation in the GDP-b ...[more]

PMID: 21636901

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Crystal structure of YjeQ from Thermotoga maritima contains a circularly permuted GTPase domain.

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Characterization of GTPase activity of TrmE, a member of a novel GTPase superfamily, from Thermotoga maritima.

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An autoinhibited state in the structure of Thermotoga maritima NusG.

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High-resolution structure of RNase P protein from Thermotoga maritima.

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Transcriptome analysis of Thermotoga maritima

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-08-02 | GSE37483 | GEO

Dihydrodipicolinate synthase from Thermotoga maritima.

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Crystal structure of the flagellar rotor protein FliN from Thermotoga maritima.

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