Systematic identification of immunodominant CD8+ T-cell responses to influenza A virus in HLA-A2 individuals.

ABSTRACT: Immunodominant T-cell responses are important for virus clearance. However, the identification of immunodominant T-cell peptide + HLA glycoprotein epitopes has been hindered by the extent of HLA polymorphism and the limitations of predictive algorithms. A simple, systematic approach has been used here to screen for immunodominant CD8(+) T-cell specificities. The analysis targeted healthy HLA-A2(+) donors to allow comparison with responses to the well-studied influenza matrix protein 1 epitope. Although influenza matrix protein 1 was consistently detected in all individual samples in our study, the response to this epitope was only immunodominant in three of eight, whereas for the other five, prominent CD8(+) T-cell responses tended to focus on various peptides from the influenza nucleoprot

SUBMITTER: Wu C 

PROVIDER: S-EPMC3107317 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature