Ontology highlight
ABSTRACT:
SUBMITTER: Humphreys BD
PROVIDER: S-EPMC3107336 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Humphreys Benjamin D BD Czerniak Suzanne S DiRocco Derek P DP Hasnain Wirasat W Cheema Rabia R Bonventre Joseph V JV
Proceedings of the National Academy of Sciences of the United States of America 20110516 22
Recently we have established that the kidney tubular epithelium is repaired by surviving epithelial cells. It is not known, however, whether a population of intratubular adult progenitor cells are responsible for this epithelial repair after acute kidney injury. In this study, we used an unbiased DNA analog-based approach that does not rely on candidate markers to track multiple rounds of cell division in vivo. In the proximal tubule, robust thymidine analog incorporation was observed postinjury ...[more]