Ontology highlight
ABSTRACT:
SUBMITTER: Jin L
PROVIDER: S-EPMC3107388 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Jin L L Xu L-G LG Yang I V IV Davidson E J EJ Schwartz D A DA Wurfel M M MM Cambier J C JC
Genes and immunity 20110120 4
MPYS, also known as STING and MITA, is an interferon (IFN)β stimulator essential for host defense against RNA, DNA viruses and intracellular bacteria. MPYS also facilitates the adjuvant activity of DNA vaccines. Here, we report identification of a distinct human MPYS haplotype that contains three non-synonymous single nucleotide polymorphisms (SNPs), R71H-G230A-R293Q (thus, named the HAQ haplotype). We estimate, in two cohorts (1,074 individuals), that ∼3% of Americans are homozygous for this HA ...[more]