Ontology highlight
ABSTRACT:
SUBMITTER: McCole RB
PROVIDER: S-EPMC3107425 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
McCole Ruth B RB Loughran Noeleen B NB Chahal Mandeep M Fernandes Luis P LP Roberts Roland G RG Fraternali Franca F O'Connell Mary J MJ Oakey Rebecca J RJ
Evolution; international journal of organic evolution 20110110 5
Retroposition is a widespread phenomenon resulting in the generation of new genes that are initially related to a parent gene via very high coding sequence similarity. We examine the evolutionary fate of four retrogenes generated by such an event; mouse Inpp5f_v2, Mcts2, Nap1l5, and U2af1-rs1. These genes are all subject to the epigenetic phenomenon of parental imprinting. We first provide new data on the age of these retrogene insertions. Using codon-based models of sequence evolution, we show ...[more]