Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection.

ABSTRACT:

Background

High-throughput genome-wide techniques have facilitated the identification of previously unknown host proteins involved in cellular human immunodeficiency virus (HIV) infection. Recently, 3 independent studies have used small interfering RNA technology to silence each gene in the human genome to determine the importance of each in HIV infection. Genes conferring a significant effect were termed HIV-dependency factors (HDFs).

Methods

We assembled high-density panels of 6380 single-nucleotide polymorphisms (SNPs) in 278 HDF genes and tested for genotype associations with HIV infection and AIDS progression in 1633 individuals from clinical AIDS cohorts.

Results

After statistical correction for multiple tests, significant associations with HIV acquisition were

SUBMITTER: Chinn LW 

PROVIDER: S-EPMC3107555 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature