Ontology highlight
ABSTRACT:
SUBMITTER: Dorff TB
PROVIDER: S-EPMC3107759 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Dorff Tanya B TB Flaig Thomas W TW Tangen Catherine M CM Hussain Maha H A MH Swanson Gregory P GP Wood David P DP Sakr Wael A WA Dawson Nancy A NA Haas Naomi B NB Crawford E David ED Vogelzang Nicholas J NJ Thompson Ian M IM Glode L Michael LM
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110418 15
<h4>Purpose</h4>Men with high-risk features (extraprostatic extension or high Gleason grade) face a high risk of prostate cancer recurrence after radical prostatectomy. Clinical trials of adjuvant systemic therapy for such patients have been limited.<h4>Patients and methods</h4>The SWOG (Southwest Oncology Group) S9921 study randomly assigned 983 men with high-risk features at prostatectomy to receive adjuvant therapy with androgen deprivation (ADT) alone or in combination with mitoxantrone chem ...[more]