Ontology highlight
ABSTRACT:
SUBMITTER: Brindley MA
PROVIDER: S-EPMC3107944 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Virology 20110506 2
In a bioinformatics-based screen for cellular genes that enhance Zaire ebolavirus (ZEBOV) transduction, AXL mRNA expression strongly correlated with ZEBOV infection. A series of cell lines and primary cells were identified that require Axl for optimal ZEBOV entry. Using one of these cell lines, we identified ZEBOV entry events that are Axl-dependent. Interactions between ZEBOV-GP and the Axl ectodomain were not detected in immunoprecipitations and reduction of surface-expressed Axl by RNAi did n ...[more]