Localization of mariner DNA transposons in the human genome by PRINS.
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ABSTRACT:
SUBMITTER: Reiter LT
PROVIDER: S-EPMC310809 | biostudies-literature | 1999 Sep
REPOSITORIES: biostudies-literature
Publications
Localization of mariner DNA transposons in the human genome by PRINS.
Reiter L T LT Liehr T T Rautenstrauss B B Robertson H M HM Lupski J R JR
Genome research 19990901 9
Homologous recombination occurring among misaligned repeated sequences is a significant source of the molecular rearrangements resulting in human genetic disease. Studies of the Charcot-Marie-Tooth disease locus on chromosome 17 have implicated the involvement of an ancient DNA transposon of the mariner family (Hsmar2) in the initiation of double-strand break events leading to homologous recombination. In this study, the genomic locations of 109 Hsmar2 elements were determined by primed in situ ...[more]
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