Identification of candidate coding region single nucleotide polymorphisms in 165 human genes using assembled expressed sequence tags.
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ABSTRACT:
SUBMITTER: Garg K
PROVIDER: S-EPMC310835 | biostudies-literature | 1999 Nov
REPOSITORIES: biostudies-literature
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Identification of candidate coding region single nucleotide polymorphisms in 165 human genes using assembled expressed sequence tags.
Garg K K Green P P Nickerson D A DA
Genome research 19991101 11
Using assembled expressed sequence tags (ESTs) from 50 different cDNA libraries, we have identified contigs that represent the complete coding sequences of 850 known human genes, and have scanned these for high quality sequence substitutions. We report the identification and characteristics of 201 candidate single nucleotide polymorphisms found in the coding sequences (cSNPs) of 165 of these genes. Using a conservative calculation, coding region nucleotide diversity (the average number of differ ...[more]
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