Interleukin-8 gene promoter polymorphism (rs4073) may contribute to chronic periodontitis.

ABSTRACT:

Background

The proinflammatory chemokine interleukin (IL)-8 is important in the regulation of the inflammatory response. Analyses of the single nucleotide polymorphism (SNP) reference sequence (rs) 4073 showed that the A allele upregulated IL-8 levels after stimulation with lipopolysaccharides. We investigated the association of the SNP rs4073 with chronic periodontitis.

Methods

Genotyping was performed by a standard polymerase chain reaction-restriction fragment length polymorphism assay in 289 genomic DNA samples of healthy control subjects and patients with chronic periodontitis; analyses were adjusted by multivariate logistic regression modeling. A real-time polymerase chain reaction performance was used to detect levels of the IL-8 mRNA.

Results

The analysis poin

SUBMITTER: Andia DC 

PROVIDER: S-EPMC3108494 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature