MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling.
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ABSTRACT:
SUBMITTER: Bershteyn M
PROVIDER: S-EPMC3108505 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling.
Bershteyn Marina M Atwood Scott X SX Woo Wei-Meng WM Li Mischa M Oro Anthony E AE
Developmental cell 20100801 2
The primary cilium is critical for transducing Sonic hedgehog (Shh) signaling, but the mechanisms of its transient assembly are poorly understood. Previously we showed that the actin regulatory protein Missing-in-Metastasis (MIM) regulates Shh signaling, but the nature of MIM's role was unknown. Here we show that MIM is required at the basal body of mesenchymal cells for cilia maintenance, Shh responsiveness, and de novo hair follicle formation. MIM knockdown results in increased Src kinase acti ...[more]
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