Ontology highlight
ABSTRACT:
SUBMITTER: Crisafulli C
PROVIDER: S-EPMC3108562 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Frontiers in pharmacology 20110216
Up to 60% of depressed patients do not respond completely to antidepressants (ADs) and up to 30% do not respond at all. Genetic factors contribute for about 50% of the AD response. During the recent years the possible influence of a set of candidate genes as genetic predictors of AD response efficacy was investigated by us and others. They include the cytochrome P450 superfamily, the P-glycoprotein (ABCB1), the tryptophan hydroxylase, the catechol-O-methyltransferase, the monoamine oxidase A, th ...[more]