Ontology highlight
ABSTRACT:
SUBMITTER: Tang X
PROVIDER: S-EPMC3108596 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Tang Xiaoli X Li Ming M Tucker Lynne L Ramratnam Bharat B
PloS one 20110603 6
The canonical microRNA (miRNA) pathway commences with the enzymatic cleavage of the primary gene transcript (pri-miRNA) by the RNAase III enzyme Drosha in the nucleus into shorter pre-miRNA species that are subsequently exported to the cytoplasm for further processing into shorter, mature miRNA molecules. Using a series of reporter constructs, we have previously demonstrated that phosphorylation of Drosha at Ser 300 and 302 was required for its nuclear localization. Here, we identify GSK3β as th ...[more]