Ontology highlight
ABSTRACT:
SUBMITTER: Ishihara K
PROVIDER: S-EPMC310880 | biostudies-literature | 2000 May
REPOSITORIES: biostudies-literature
Ishihara K K Hatano N N Furuumi H H Kato R R Iwaki T T Miura K K Jinno Y Y Sasaki H H
Genome research 20000501 5
A differentially methylated region (DMR) and endoderm-specific enhancers, located upstream and downstream of the mouse H19 gene, respectively, are known to be essential for the reciprocal imprinting of Igf2 and H19. To explain the same imprinting patterns in non-endodermal tissues, additional enhancers have been hypothesized. We determined and compared the sequences of human and mouse H19 over 40 kb and identified 10 evolutionarily conserved downstream segments, 2 of which were coincident with t ...[more]