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Differential regulation of diacylglycerol kinase isoform in human failing hearts.


ABSTRACT: Evidence from several studies indicates the importance of G?q protein-coupled receptor (GPCR) signaling pathway, which includes diacylglycerol (DAG), and protein kinase C, in the development of heart failure. DAG kinase (DGK) acts as an endogenous regulator of GPCR signaling pathway by catalyzing and regulating DAG. Expressions of DGK isoforms ?, ?, and ? in rodent hearts have been detected; however, the expression and alteration of DGK isoforms in a failing human heart has not yet been examined. In this study, we detected mRNA expressions of DGK isoforms ?, ?, ?, and ? in failing human heart samples obtained from patients undergoing cardiovascular surgery with cardiopulmonary bypass. Furthermore, we investigated modulation of DGK isoform expression in these hearts. We found that expressions of DGK? and DGK? were increased and decreased, respectively, whereas those of DGK? and DGK? remained unchanged. This is the first report that describes the differential regulation of DGK isoforms in normal and failing human hearts.

SUBMITTER: Bilim O 

PROVIDER: S-EPMC3108920 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Differential regulation of diacylglycerol kinase isoform in human failing hearts.

Bilim Olga O   Shishido Tetsuro T   Toyama Shuji S   Suzuki Satoshi S   Sasaki Toshiki T   Kitahara Tatsuro T   Sadahiro Mitsuaki M   Takeishi Yasuchika Y   Kubota Isao I  

Journal of cardiothoracic surgery 20110508


Evidence from several studies indicates the importance of Gαq protein-coupled receptor (GPCR) signaling pathway, which includes diacylglycerol (DAG), and protein kinase C, in the development of heart failure. DAG kinase (DGK) acts as an endogenous regulator of GPCR signaling pathway by catalyzing and regulating DAG. Expressions of DGK isoforms α, ε, and ζ in rodent hearts have been detected; however, the expression and alteration of DGK isoforms in a failing human heart has not yet been examined  ...[more]

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