Differential regulation of diacylglycerol kinase isoform in human failing hearts.
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ABSTRACT:
SUBMITTER: Bilim O
PROVIDER: S-EPMC3108920 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Differential regulation of diacylglycerol kinase isoform in human failing hearts.
Bilim Olga O Shishido Tetsuro T Toyama Shuji S Suzuki Satoshi S Sasaki Toshiki T Kitahara Tatsuro T Sadahiro Mitsuaki M Takeishi Yasuchika Y Kubota Isao I
Journal of cardiothoracic surgery 20110508
Evidence from several studies indicates the importance of Gαq protein-coupled receptor (GPCR) signaling pathway, which includes diacylglycerol (DAG), and protein kinase C, in the development of heart failure. DAG kinase (DGK) acts as an endogenous regulator of GPCR signaling pathway by catalyzing and regulating DAG. Expressions of DGK isoforms α, ε, and ζ in rodent hearts have been detected; however, the expression and alteration of DGK isoforms in a failing human heart has not yet been examined ...[more]
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