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Active conservation of noncoding sequences revealed by three-way species comparisons.

ABSTRACT: Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human-mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.

SUBMITTER: Dubchak I

PROVIDER: S-EPMC310906 | biostudies-literature | 2000 Sep

REPOSITORIES: biostudies-literature

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Active conservation of noncoding sequences revealed by three-way species comparisons.

Dubchak I I Brudno M M Loots G G GG Pachter L L Mayor C C Rubin E M EM Frazer K A KA

Genome research 20000901 9

Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human-mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time. ...[more]

PMID: 10984448

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