Ontology highlight
ABSTRACT:
SUBMITTER: Curtiss ML
PROVIDER: S-EPMC3109159 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Curtiss Miranda L ML Hostager Bruce S BS Stepniak Elizabeth E Singh Melody M Manhica Natalie N Knisz Judit J Traver Geri G Rennert Paul D PD Colgan John D JD Rothman Paul B PB
Molecular immunology 20110421 12-13
The gene encoding T cell immunoglobulin and mucin domain-1 (Tim-1) is linked to atopy and asthma susceptibility in mice and humans. Tim-1 is a transmembrane protein expressed on activated lymphocytes and appears to have a role as a co-stimulatory receptor in T cells. The protein has not been shown to have enzymatic activity but contains a site within its cytoplasmic tail predicted to be a target for tyrosine kinases. Here, we show that Tim-1 can associate with the kinase Fyn, a member of the Src ...[more]