Ontology highlight
ABSTRACT:
SUBMITTER: Ye L
PROVIDER: S-EPMC3109609 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20100501 9
Deletion of phenylalanine residue 508 (DeltaF508) in the cystic fibrosis (CF) transmembrane conductance regulator protein (CFTR) is a major cause of CF. Small molecule "correctors" of defective DeltaF508-CFTR cellular processing hold promise for CF therapy. We previously identified and characterized bithiazole CF corrector 1 and s-cis-locked bithiazole 2. Herein, we report the regiodivergent synthesis of Ngamma and Nbeta isomers of thiazole-tethered pyrazoles with improved hydrophilicity compare ...[more]