Ontology highlight
ABSTRACT:
SUBMITTER: Tian Y
PROVIDER: S-EPMC3109869 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20110508 6
Trax-translin heteromers, also known as C3PO, have been proposed to activate the RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand. We report on the crystal structure of hexameric Drosophila C3PO formed by truncated translin and Trax, along with electron microscopic and mass spectrometric studies on octameric C3PO formed by full-length translin and Trax. Our studies establish that Trax adopts the translin fold, possesses catalytic centers ...[more]