Ontology highlight
ABSTRACT:
SUBMITTER: Fan TW
PROVIDER: S-EPMC3109995 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Metabolomics : Official journal of the Metabolomic Society 20110601 2
We have determined the time course of [U-(13)C]-glucose utilization and transformations in SCID mice via bolus injection of the tracer in the tail vein. Incorporation of (13)C into metabolites extracted from mouse blood plasma and several tissues (lung, heart, brain, liver, kidney, and skeletal muscle) were profiled by NMR and GC-MS, which helped ascertain optimal sampling times for different target tissues. We found that the time for overall optimal (13)C incorporation into tissue was 15-20 min ...[more]