An assessment of CETP sequence variation in relation to cognitive decline and dementia risk.
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ABSTRACT:
SUBMITTER: Reynolds CA
PROVIDER: S-EPMC3110386 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
An assessment of CETP sequence variation in relation to cognitive decline and dementia risk.
Reynolds Chandra A CA Gatz Margaret M Pedersen Nancy L NL Prince Jonathan A JA
International journal of molecular epidemiology and genetics 20110310 2
The gene encoding the cholesteryl ester transfer protein (CETP) plays an integral role in lipid metabolism. We evaluated common genetic variation spanning CETP for association with cognitive decline as well as incident and prevalent dementia and Alzheimer disease risk. Data from four population-based twin studies and a case-control sample were included, encompassing an analysis sample of 1513 dementia cases and 2137 controls with available CETP genotypes and covariates. Memory and perceptual spe ...[more]
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