Ontology highlight
ABSTRACT:
SUBMITTER: Bales JW
PROVIDER: S-EPMC3110667 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Bales James W JW Yan Hong Q HQ Ma Xiecheng X Li Youming Y Samarasinghe Ranmal R Dixon C Edward CE
Experimental neurology 20110301 2
Traumatic brain injury (TBI) causes persistent neurologic deficits. Current therapies, predominantly focused upon cortical and hippocampal cellular survival, have limited benefit on cognitive outcomes. Striatal damage is associated with deficits in executive function, learning, and memory. Dopamine and cAMP regulated phosphoprotein 32 (DARPP-32) is expressed within striatal medium spiny neurons and regulates striatal function. We found that controlled cortical impact injury in rats produces a ch ...[more]