Macrophages in the pathogenesis of atherosclerosis.
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ABSTRACT:
SUBMITTER: Moore KJ
PROVIDER: S-EPMC3111065 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
In atherosclerosis, the accumulation of apolipoprotein B-lipoproteins in the matrix beneath the endothelial cell layer of blood vessels leads to the recruitment of monocytes, the cells of the immune system that give rise to macrophages and dendritic cells. Macrophages derived from these recruited monocytes participate in a maladaptive, nonresolving inflammatory response that expands the subendothelial layer due to the accumulation of cells, lipid, and matrix. Some lesions subsequently form a nec ...[more]
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