Ontology highlight
ABSTRACT:
SUBMITTER: Bhattacharyya S
PROVIDER: S-EPMC3111275 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Bhattacharyya Sandip S Zhao Yuxing Y Kay Thomas W H TW Muglia Louis J LJ
Proceedings of the National Academy of Sciences of the United States of America 20110523 23
Endogenous and pharmacologic glucocorticoids (GCs) limit inflammatory cascades initiated by Toll-like receptor (TLR) activation. A long-standing clinical observation has been the delay between GC administration and the manifestation of GC's anti-inflammatory actions. We hypothesized that the GCs would have inhibitory effects that target late temporal pathways that propagate proinflammatory signals. Here we interrogated signal transducer and activator of transcription 1 (STAT1) regulation by GC a ...[more]