Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC3111296 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Li Li L Boniecki Michal T MT Jaffe Jacob D JD Imai Brian S BS Yau Peter M PM Luthey-Schulten Zaida A ZA Martinis Susan A SA
Proceedings of the National Academy of Sciences of the United States of America 20110523 23
Mycoplasma parasites escape host immune responses via mechanisms that depend on remarkable phenotypic plasticity. Identification of these mechanisms is of great current interest. The aminoacyl-tRNA synthetases (AARSs) attach amino acids to their cognate tRNAs, but occasionally make errors that substitute closely similar amino acids. AARS editing pathways clear errors to avoid mistranslation during protein synthesis. We show here that AARSs in Mycoplasma parasites have point mutations and deletio ...[more]