Ontology highlight
ABSTRACT:
SUBMITTER: Myers SA
PROVIDER: S-EPMC3111310 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Myers Samuel A SA Panning Barbara B Burlingame Alma L AL
Proceedings of the National Academy of Sciences of the United States of America 20110523 23
The monosaccharide addition of an N-acetylglucosamine to serine and threonine residues of nuclear and cytosolic proteins (O-GlcNAc) is a posttranslational modification emerging as a general regulator of many cellular processes, including signal transduction, cell division, and transcription. The sole mouse O-GlcNAc transferase (OGT) is essential for embryonic development. To understand the role of OGT in mouse development better, we mapped sites of O-GlcNAcylation of nuclear proteins in mouse em ...[more]