Ontology highlight
ABSTRACT:
SUBMITTER: Nash AI
PROVIDER: S-EPMC3111320 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Nash Abigail I AI McNulty Reginald R Shillito Mary Elizabeth ME Swartz Trevor E TE Bogomolni Roberto A RA Luecke Hartmut H Gardner Kevin H KH
Proceedings of the National Academy of Sciences of the United States of America 20110523 23
Light-oxygen-voltage (LOV) domains are blue light-activated signaling modules integral to a wide range of photosensory proteins. Upon illumination, LOV domains form internal protein-flavin adducts that generate conformational changes which control effector function. Here we advance our understanding of LOV regulation with structural, biophysical, and biochemical studies of EL222, a light-regulated DNA-binding protein. The dark-state crystal structure reveals interactions between the EL222 LOV an ...[more]