Ontology highlight
ABSTRACT:
SUBMITTER: Kohli MA
PROVIDER: S-EPMC3112053 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Neuron 20110401 2
Major depression (MD) is one of the most prevalent psychiatric disorders and a leading cause of loss in work productivity. A combination of genetic and environmental risk factors probably contributes to MD. We present data from a genome-wide association study revealing a neuron-specific neutral amino acid transporter (SLC6A15) as a susceptibility gene for MD. Risk allele carrier status in humans and chronic stress in mice were associated with a downregulation of the expression of this gene in th ...[more]