Dengue virus tropism in humanized mice recapitulates human dengue fever.
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ABSTRACT:
SUBMITTER: Mota J
PROVIDER: S-EPMC3112147 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
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Dengue virus tropism in humanized mice recapitulates human dengue fever.
Mota Javier J Rico-Hesse Rebeca R
PloS one 20110610 6
Animal models of dengue virus disease have been very difficult to develop because of the virus' specificity for infection and replication in certain human cells. We developed a model of dengue fever in immunodeficient mice transplanted with human stem cells from umbilical cord blood. These mice show measurable signs of dengue disease as in humans (fever, viremia, erythema and thrombocytopenia), and after infection with the most virulent strain of dengue serotype 2, humanized mice showed infectio ...[more]
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