Advanced integrated mouse YAC map including BAC framework.
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ABSTRACT:
SUBMITTER: Schalkwyk LC
PROVIDER: S-EPMC311217 | biostudies-literature | 2001 Dec
REPOSITORIES: biostudies-literature
Publications
Advanced integrated mouse YAC map including BAC framework.
Schalkwyk L C LC Cusack B B Dunkel I I Hopp M M Kramer M M Palczewski S S Piefke J J Scheel S S Weiher M M Wenske G G Lehrach H H Himmelbauer H H
Genome research 20011201 12
Functional characterization of the mouse genome requires the availability of a comprehensive physical map to obtain molecular access to chromosomal regions of interest. Positional cloning remains a crucial way of linking phenotype with particular genes. A key step and frequent stumbling block in positional cloning is making a contig of a genetically defined candidate region. The most efficient first step is isolating YAC (Yeast Artificial Chromosome) clones. A robust, detailed YAC contig map is ...[more]
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