Thyroid-specific transcription factors and their roles in thyroid cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: Kimura S
PROVIDER: S-EPMC3112524 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Thyroid-specific transcription factors and their roles in thyroid cancer.
Journal of thyroid research 20110428
Homeodomain, forkhead domain, and paired domain-containing transcription factors play a major role in development, tissue-specific gene expression, and tissue homeostasis in organs where they are expressed. Recently, their roles in stem cell and cancer biology are emerging. In the thyroid, NKX2-1, FOXE1, and PAX8 transcription factors are responsible for thyroid organogenesis and expression of thyroid-specific genes critical for thyroid hormone synthesis. In contrast to their known roles in gene ...[more]
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