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Protein abundances are more conserved than mRNA abundances across diverse taxa.

ABSTRACT: Proteins play major roles in most biological processes; as a consequence, protein expression levels are highly regulated. While extensive post-transcriptional, translational and protein degradation control clearly influence protein concentration and functionality, it is often thought that protein abundances are primarily determined by the abundances of the corresponding mRNAs. Hence surprisingly, a recent study showed that abundances of orthologous nematode and fly proteins correlate better than their corresponding mRNA abundances. We tested if this phenomenon is general by collecting and testing matching large-scale protein and mRNA expression data sets from seven different species: two bacteria, yeast, nematode, fly, human, and rice. We find that steady-state abundances of proteins show significantly higher correlation across these diverse phylogenetic taxa than the abundances of their corresponding mRNAs (p=0.0008, paired Wilcoxon). These data support the presence of strong selective pressure to maintain protein abundances during evolution, even when mRNA abundances diverge.

SUBMITTER: Laurent JM

PROVIDER: S-EPMC3113407 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Protein abundances are more conserved than mRNA abundances across diverse taxa.

Laurent Jon M JM Vogel Christine C Kwon Taejoon T Craig Stephanie A SA Boutz Daniel R DR Huse Holly K HK Nozue Kazunari K Walia Harkamal H Whiteley Marvin M Ronald Pamela C PC Marcotte Edward M EM

Proteomics 20101201 23

Proteins play major roles in most biological processes; as a consequence, protein expression levels are highly regulated. While extensive post-transcriptional, translational and protein degradation control clearly influence protein concentration and functionality, it is often thought that protein abundances are primarily determined by the abundances of the corresponding mRNAs. Hence surprisingly, a recent study showed that abundances of orthologous nematode and fly proteins correlate better than ...[more]

PMID: 21089048

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Protein abundances are more conserved than mRNA abundances across diverse taxa.

Publications

Protein abundances are more conserved than mRNA abundances across diverse taxa.

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