Ontology highlight
ABSTRACT:
SUBMITTER: Tang T
PROVIDER: S-EPMC3113453 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Tang Tracy T Tang Jean Y JY Li Dongwei D Reich Mike M Callahan Christopher A CA Fu Ling L Yauch Robert L RL Wang Frank F Kotkow Karen K Chang Kris S KS Shpall Elana E Wu Angela A Rubin Lee L LL Marsters James C JC Epstein Ervin H EH Caro Ivor I de Sauvage Frederic J FJ
Clinical cancer research : an official journal of the American Association for Cancer Research 20110510 10
<h4>Purpose</h4>Inappropriate activation of the Hedgehog (Hh) signaling pathway in skin is critical for the development of basal cell carcinomas (BCC). We have investigated the anti-BCC efficacy of topically-applied CUR61414, an inhibitor of the Hh signal transduction molecule Smoothened.<h4>Experimental design</h4>In preclinical studies, we used a depilatory model to evaluate the ability of topical formulations of CUR61414 to repress Hh responsive cells found at the base of hair follicles in no ...[more]