Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response.
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ABSTRACT:
SUBMITTER: Ji Y
PROVIDER: S-EPMC3113454 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Publications
Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response.
Ji Y Y Biernacka J J Snyder K K Drews M M Pelleymounter L L LL Colby C C Wang L L Mrazek D A DA Weinshilboum R M RM
The pharmacogenomics journal 20100928 1
We applied a systematic pharmacogenetic approach to investigate the role of genetic variation in the gene encoding catechol O-methyltransferase (COMT) in individual variation in selective serotonin reuptake inhibitor (SSRI) response among depressed patients. In all, 23 single-nucleotide polymorphisms (SNPs) in COMT were genotyped using DNA from the Sequenced Treatment Alternatives to Relieve Depression (STAR(*)D) study (N=1914). One SNP, rs13306278, located in the distal promoter region of COMT, ...[more]
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