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Retinal imaging with polarization-sensitive optical coherence tomography and adaptive optics.


ABSTRACT: Various layers of the retina are well known to alter the polarization state of light. Such changes in polarization may be a sensitive indicator of tissue structure and function, and as such have gained increased clinical attention. Here we demonstrate a polarization-sensitive optical coherence tomography (PS-OCT) system that incorporates adaptive optics (AO) in the sample arm and a single line scan camera in the detection arm. We quantify the benefit of AO for PS-OCT in terms of signal-to-noise, lateral resolution, and speckle size. Double pass phase retardation per unit depth values ranging from 0.25 degrees/microm to 0.65 degrees/microm were found in the birefringent nerve fiber layer at 6 degrees eccentricity, superior to the fovea, with the highest values being noticeably higher than previously reported with PS-OCT around the optic nerve head. Moreover, fast axis orientation and degree of polarization uniformity measurements made with AO-PS-OCT demonstrate polarization scrambling in the retinal pigment epithelium at the highest resolution reported to date.

SUBMITTER: Cense B 

PROVIDER: S-EPMC3113602 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature

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Retinal imaging with polarization-sensitive optical coherence tomography and adaptive optics.

Cense Barry B   Gao Weihua W   Brown Jeffrey M JM   Jones Steven M SM   Jonnal Ravi S RS   Mujat Mircea M   Park B Hyle BH   de Boer Johannes F JF   Miller Donald T DT  

Optics express 20091101 24


Various layers of the retina are well known to alter the polarization state of light. Such changes in polarization may be a sensitive indicator of tissue structure and function, and as such have gained increased clinical attention. Here we demonstrate a polarization-sensitive optical coherence tomography (PS-OCT) system that incorporates adaptive optics (AO) in the sample arm and a single line scan camera in the detection arm. We quantify the benefit of AO for PS-OCT in terms of signal-to-noise,  ...[more]

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