Ontology highlight
ABSTRACT:
SUBMITTER: Huber S
PROVIDER: S-EPMC3113617 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Immunity 20110401 4
T helper 17 (Th17) cells are important for host defense against extracellular microorganisms. However, they are also implicated in autoimmune and chronic inflammatory diseases, and as such need to be tightly regulated. The mechanisms that directly control committed pathogenic Th17 cells in vivo remain unclear. We showed here that IL-17A-producing CD4+ T cells expressed interleukin-10 receptor α (IL-10Rα) in vivo. Importantly, T cell-specific blockade of IL-10 signaling led to a selective increas ...[more]