Ontology highlight
ABSTRACT:
SUBMITTER: Zhang JS
PROVIDER: S-EPMC3113775 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Zhang Jin-San JS Koenig Alexander A Young Charles C Billadeau Daniel D DD
Molecular biology of the cell 20110420 12
RhoU is an atypical Rho family member with high homology to CDC42 but containing unique N- and C-terminal extensions. The mechanisms regulating RhoU activation, as well as its downstream effectors, are not fully characterized. We show that after epidermal growth factor (EGF) stimulation RhoU colocalizes with EGF receptor (EGFR) on endosomes, which requires both its N- and C-terminal extension sequences. Moreover, RhoU physically associates with activated EGFR in a GRB2-dependent manner through s ...[more]