Ontology highlight
ABSTRACT:
SUBMITTER: Becker EB
PROVIDER: S-EPMC3114078 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Cerebellum (London, England) 20110601 2
The hereditary cerebellar ataxias are a diverse group of neurodegenerative disorders primarily characterised by loss of balance and coordination due to dysfunction of the cerebellum and its associated pathways. Although many genetic mutations causing inherited cerebellar ataxia have been identified, a significant percentage of patients remain whose cause is unknown. The transient receptor potential (TRP) family member TRPC3 is a non-selective cation channel linked to key signalling pathways that ...[more]