Unknown

Dataset Information

0

Association of maternal genital and reproductive infections with verbal memory and motor deficits in adult schizophrenia.


ABSTRACT: Maternal exposure to genital and reproductive infections has been associated with schizophrenia in previous studies. Impairments in several neuropsychological functions, including verbal memory, working memory, executive function, and fine-motor coordination occur prominently in patients with schizophrenia. The etiologies of these deficits, however, remain largely unknown. We aimed to assess whether prospectively documented maternal exposure to genital/reproductive (G/R) infections was related to these neuropsychological deficits in offspring with schizophrenia and other schizophrenia spectrum disorders. The cases were derived from a population-based birth cohort; all cohort members belonged to a prepaid health plan. Cases were assessed for verbal memory, working memory, executive function, and fine-motor coordination. Compared to unexposed cases, patients exposed to maternal genital/reproductive infection performed more poorly on verbal memory, fine-motor coordination, and working memory. Stratification by race revealed associations between maternal G/R infection and verbal memory and fine-motor coordination for case offspring of African-American mothers, but not for case offspring of White mothers. Significant infection-by-race interactions were also observed. Although independent replications are warranted, maternal G/R infections were associated with verbal memory and motor function deficits in African-American patients with schizophrenia.

SUBMITTER: Brown AS 

PROVIDER: S-EPMC3114294 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Association of maternal genital and reproductive infections with verbal memory and motor deficits in adult schizophrenia.

Brown Alan S AS   Vinogradov Sophia S   Kremen William S WS   Poole John H JH   Bao Yuanyuan Y   Kern David D   McKeague Ian W IW  

Psychiatry research 20110519 2


Maternal exposure to genital and reproductive infections has been associated with schizophrenia in previous studies. Impairments in several neuropsychological functions, including verbal memory, working memory, executive function, and fine-motor coordination occur prominently in patients with schizophrenia. The etiologies of these deficits, however, remain largely unknown. We aimed to assess whether prospectively documented maternal exposure to genital/reproductive (G/R) infections was related t  ...[more]

Similar Datasets

| S-EPMC8631787 | biostudies-literature
| S-EPMC2885958 | biostudies-literature
| S-EPMC9313460 | biostudies-literature
| S-EPMC2720319 | biostudies-literature
| S-EPMC5473910 | biostudies-literature
| S-EPMC10089087 | biostudies-literature
| S-EPMC2949490 | biostudies-literature
| S-EPMC2902762 | biostudies-literature
| S-EPMC5434108 | biostudies-literature
| S-EPMC8211872 | biostudies-literature