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Pharmacokinetics and pharmacodynamics of therapeutic doses of basal insulins NPH, glargine, and detemir after 1 week of daily administration at bedtime in type 2 diabetic subjects: a randomized cross-over study.


ABSTRACT:

Objective

To compare the pharmacokinetics and pharmacodynamics of NPH, glargine, and detemir insulins in type 2 diabetic subjects.

Research design and methods

This study used a single-blind, three-way, cross-over design. A total of 18 type 2 diabetic subjects underwent a euglycemic clamp for 32 h after a subcutaneous injection of 0.4 units/kg at 2200 h of either NPH, glargine, or detemir after 1 week of bedtime treatment with each insulin.

Results

The glucose infusion rate area under the curve(0-32 h) was greater for glargine than for detemir and NPH (1,538 ± 688; 1,081 ± 785; and 1,170 ± 703 mg/kg, respectively; P < 0.05). Glargine suppressed endogenous glucose production more than detemir (P < 0.05) and similarly to NPH (P = 0.16). Glucagon, C-peptide, free fatty acids, and ?-hydroxy-butyrate were more suppressed with glargine than detemir. All 18 subjects completed the glargine study, but two subjects on NPH and three on detemir interrupted the study because of plasma glucose >150 mg/dL.

Conclusions

Compared with NPH and detemir, glargine provided greater metabolic activity and superior glucose control for up to 32 h.

SUBMITTER: Lucidi P 

PROVIDER: S-EPMC3114339 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Publications

Pharmacokinetics and pharmacodynamics of therapeutic doses of basal insulins NPH, glargine, and detemir after 1 week of daily administration at bedtime in type 2 diabetic subjects: a randomized cross-over study.

Lucidi Paola P   Porcellati Francesca F   Rossetti Paolo P   Candeloro Paola P   Cioli Patrizia P   Marzotti Stefania S   Andreoli Anna Marinelli AM   Fede Raffaela R   Bolli Geremia B GB   Fanelli Carmine G CG  

Diabetes care 20110415 6


<h4>Objective</h4>To compare the pharmacokinetics and pharmacodynamics of NPH, glargine, and detemir insulins in type 2 diabetic subjects.<h4>Research design and methods</h4>This study used a single-blind, three-way, cross-over design. A total of 18 type 2 diabetic subjects underwent a euglycemic clamp for 32 h after a subcutaneous injection of 0.4 units/kg at 2200 h of either NPH, glargine, or detemir after 1 week of bedtime treatment with each insulin.<h4>Results</h4>The glucose infusion rate  ...[more]

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