Ontology highlight
ABSTRACT:
SUBMITTER: Sanna D
PROVIDER: S-EPMC3115307 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Sanna Daria D Pala Maria M Cossu Piero P Dedola Gian Luca GL Melis Sonia S Fresu Giovanni G Morelli Laura L Obinu Domenica D Tonolo Giancarlo G Secchi Giannina G Triunfo Riccardo R Lorenz Joseph G JG Scheinfeldt Laura L Torroni Antonio A Robledo Renato R Francalacci Paolo P
Genetics and molecular biology 20110401 2
We report a sampling strategy based on Mendelian Breeding Units (MBUs), representing an interbreeding group of individuals sharing a common gene pool. The identification of MBUs is crucial for case-control experimental design in association studies. The aim of this work was to evaluate the possible existence of bias in terms of genetic variability and haplogroup frequencies in the MBU sample, due to severe sample selection. In order to reach this goal, the MBU sampling strategy was compared to a ...[more]