Genetic biomarkers of health-related quality of life in pediatric asthma.
Ontology highlight
ABSTRACT: Objectives
To determine the relationship between single nucleotide polymorphisms in candidate genes associated with multiple asthma phenotypes and health-related quality of life (HRQOL).Study design
A cross-sectional study was conducted at a pediatric hospital in 275 school-aged children diagnosed with asthma and their caregivers. Genomic DNA was obtained from children, and caregivers completed a measure of their child's HRQOL. Analysis of variance was used to investigate the association between single nucleotide polymorphisms and HRQOL.Results
Children homozygous for the major variant at IL-4RA rs 1805010 had significantly better HRQOL than their counterparts. Significant associations with pulmonary function were not observed.Conclusions
Genes associated with asthma phenotype can be associated with HRQOL at least partly independent of pulmonary function.
SUBMITTER: Cortina SD
PROVIDER: S-EPMC3115404 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
Genetic biomarkers of health-related quality of life in pediatric asthma.
Cortina Sandra D SD Drotar Dennis D Ericksen Mark M Lindsey Mark M Patterson Tia L TL Myers Jocelyn M Biagini JM Kovacic Melinda Butsch MB Hershey Gurjit K Khurana GK
The Journal of pediatrics 20110215 1
<h4>Objectives</h4>To determine the relationship between single nucleotide polymorphisms in candidate genes associated with multiple asthma phenotypes and health-related quality of life (HRQOL).<h4>Study design</h4>A cross-sectional study was conducted at a pediatric hospital in 275 school-aged children diagnosed with asthma and their caregivers. Genomic DNA was obtained from children, and caregivers completed a measure of their child's HRQOL. Analysis of variance was used to investigate the ass ...[more]
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