Ontology highlight
ABSTRACT:
SUBMITTER: Boran AD
PROVIDER: S-EPMC3115457 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Boran Aislyn D W AD Chen Yibang Y Iyengar Ravi R
Cellular signalling 20110508 9
The role of Gβγ in adenylyl cyclase (AC) signaling is complicated due to its role as a conditional activator (AC2, AC4 and AC7) and an inhibitor (AC1, AC3 and AC8). AC2 is stimulated by Gα(s) and if Gβγ is present the stimulation is synergistic. The precise mechanism of this synergistic activation is still not known. In order to further elucidate the role of Gβγ in AC2 activation by Gα(s), peptides derived from the C1 domains of AC2 were synthesized and the ability of the various peptides to reg ...[more]