Ontology highlight
ABSTRACT:
SUBMITTER: Majumdar S
PROVIDER: S-EPMC3115495 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Majumdar Susruta S Burgman Maxim M Haselton Nathan N Grinnell Steven S Ocampo Julia J Pasternak Anna Rose AR Pasternak Gavril W GW
Bioorganic & medicinal chemistry letters 20110508 13
Tritiated opioid radioligands have proven valuable in exploring opioid binding sites. However, tritium has many limitations. Its low specific activity and limited counting efficiency makes it difficult to examine low abundant, high affinity sites and its disposal is problematic due to the need to use organic scintillants and its relatively long half-life. To overcome these issues, we have synthesized both unlabeled and carrier-free radioiodinated iodobenzoyl derivatives of 6β-naltrexamine ((125) ...[more]