Ontology highlight
ABSTRACT:
SUBMITTER: Sirinakis G
PROVIDER: S-EPMC3116276 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Sirinakis George G Clapier Cedric R CR Gao Ying Y Viswanathan Ramya R Cairns Bradley R BR Zhang Yongli Y
The EMBO journal 20110506 12
ATP-dependent chromatin remodelling complexes use the energy of ATP hydrolysis to reposition and reconfigure nucleosomes. Despite their diverse functions, all remodellers share highly conserved ATPase domains, many shown to translocate DNA. Understanding remodelling requires biophysical knowledge of the DNA translocation process: how the ATPase moves DNA and generates force, and how translocation and force generation are coupled on nucleosomes. Here, we characterize the real-time activity of a m ...[more]