Ontology highlight
ABSTRACT:
SUBMITTER: He E
PROVIDER: S-EPMC3116408 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
He Enuo E Kapuy Orsolya O Oliveira Raquel A RA Uhlmann Frank F Tyson John J JJ Novák Béla B
Proceedings of the National Academy of Sciences of the United States of America 20110526 24
The mitotic checkpoint prevents a eukaryotic cell from commencing to separate its replicated genome into two daughter cells (anaphase) until all of its chromosomes are properly aligned on the metaphase plate, with the two copies of each chromosome attached to opposite poles of the mitotic spindle. The mitotic checkpoint is exquisitely sensitive in that a single unaligned chromosome, 1 of a total of ~50, is sufficient to delay progression into anaphase; however, when the last chromosome comes int ...[more]