Ontology highlight
ABSTRACT:
SUBMITTER: Xie L
PROVIDER: S-EPMC3116421 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Xie Liang L Duncan Michael B MB Pahler Jessica J Sugimoto Hikaru H Martino Margot M Lively Julie J Mundel Thomas T Soubasakos Mary M Rubin Kristofer K Takeda Takaaki T Inoue Masahiro M Lawler Jack J Hynes Richard O RO Hanahan Douglas D Kalluri Raghu R
Proceedings of the National Academy of Sciences of the United States of America 20110527 24
Whereas the roles of proangiogenic factors in carcinogenesis are well established, those of endogenous angiogenesis inhibitors (EAIs) remain to be fully elaborated. We investigated the roles of three EAIs during de novo tumorigenesis to further test the angiogenic balance hypothesis, which suggests that blood vessel development in the tumor microenvironment can be governed by a net loss of negative regulators of angiogenesis in addition to the well-established principle of up-regulated angiogene ...[more]