Ontology highlight
ABSTRACT:
SUBMITTER: Li N
PROVIDER: S-EPMC3116441 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Li Nanxin N Lee Boyoung B Liu Rong-Jian RJ Banasr Mounira M Dwyer Jason M JM Iwata Masaaki M Li Xiao-Yuan XY Aghajanian George G Duman Ronald S RS
Science (New York, N.Y.) 20100801 5994
The rapid antidepressant response after ketamine administration in treatment-resistant depressed patients suggests a possible new approach for treating mood disorders compared to the weeks or months required for standard medications. However, the mechanisms underlying this action of ketamine [a glutamate N-methyl-D-aspartic acid (NMDA) receptor antagonist] have not been identified. We observed that ketamine rapidly activated the mammalian target of rapamycin (mTOR) pathway, leading to increased ...[more]